Homo sapiens Gene: AIP
Summary
InnateDB Gene IDBG-60515.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AIP
Gene Name aryl hydrocarbon receptor interacting protein
Synonyms ARA9; FKBP16; FKBP37; SMTPHN; XAP-2; XAP2;
Species Homo sapiens
Ensembl Gene ENSG00000110711
Encoded Proteins
aryl hydrocarbon receptor interacting protein
aryl hydrocarbon receptor interacting protein
aryl hydrocarbon receptor interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
AIP is a novel inhibitor of IRF7 and a negative regulator of innate antiviral signalling.
Entrez Gene
Summary The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:67483041-67491103
Strand Forward strand
Band q13.2
Transcripts
ENST00000279146 ENSP00000279146
ENST00000528641 ENSP00000434982
ENST00000529797
ENST00000525341 ENSP00000476993
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0036004 GAF domain binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0006626 protein targeting to mitochondrion
GO:0006805 xenobiotic metabolic process
GO:0007165 signal transduction
GO:0010738 regulation of protein kinase A signaling
GO:0022417 protein maturation by protein folding
GO:0045087 innate immune response (InnateDB)
GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Ahr signal transduction pathway [Biocarta view]
PID NCI
Cross-References
SwissProt O00170
TrEMBL A3RDR8 A7KS93 A7KS94 A7YDK1 A7YDK2 A7YDK4 A7YDK6 A8BQF1 B3TMT2 D0EKE5 E5L4L0 E9PMH2 G9I2H4 V9GYQ3
UniProt Splice Variant
Entrez Gene 9049
UniGene
RefSeq NM_003977
HUGO HGNC:358
OMIM 605555
CCDS CCDS8168
HPRD
IMGT
EMBL AM236341 AP001184 AP003419 BC104797 BC104827 EF066502 EF066504 EF066505 EF066510 EF203237 EF553638 EF553639 EF643646 EF643647 EF643648 EF643649 EF660892 EU304800 GQ847771 HQ316145 JN561683 U31913 U78521
GenPept AAB39923 AAB59004 AAI04798 AAI04828 ABK60081 ABK60082 ABK60083 ABK60084 ABO16000 ABQ45127 ABQ45128 ABV03523 ABV03524 ABV03525 ABV03526 ABV26697 ACA01869 ACX54433 ADR74098 AEW31446 CAJ85657
RNA Seq Atlas 9049