InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AIP

Summary

InnateDB Gene

IDBG-60515.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AIP

Gene Name

aryl hydrocarbon receptor interacting protein

Synonyms

ARA9; FKBP16; FKBP37; SMTPHN; XAP-2; XAP2

Species

Homo sapiens

Ensembl Gene

ENSG00000110711

Encoded Proteins

IDBP-60517

aryl hydrocarbon receptor interacting protein

IDBP-585980

aryl hydrocarbon receptor interacting protein

IDBP-807493

aryl hydrocarbon receptor interacting protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25911105

AIP is a novel inhibitor of IRF7 and a negative regulator of innate antiviral signalling.

Entrez Gene

Summary

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:67483041-67491103

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000279146	ENSP00000279146
ENST00000528641	ENSP00000434982
ENST00000529797
ENST00000525341	ENSP00000476993

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	43 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0036004	GAF domain binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0006626	protein targeting to mitochondrion
GO:0006805	xenobiotic metabolic process
GO:0007165	signal transduction
GO:0010738	regulation of protein kinase A signaling
GO:0022417	protein maturation by protein folding
GO:0045087	innate immune response (InnateDB)
GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024847

View Gene Order

ENSBTAG00000010478

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

O00170

TrEMBL

A3RDR8 A7KS93 A7KS94 A7YDK1 A7YDK2 A7YDK4 A7YDK6 A8BQF1 B3TMT2 D0EKE5 E5L4L0 E9PMH2 G9I2H4 V9GYQ3

UniProt Splice Variant

Entrez Gene

9049

UniGene

RefSeq

NM_003977

HUGO

HGNC:358

OMIM

605555

CCDS

CCDS8168

HPRD

IMGT

EMBL

AM236341 AP001184 AP003419 BC104797 BC104827 EF066502 EF066504 EF066505 EF066510 EF203237 EF553638 EF553639 EF643646 EF643647 EF643648 EF643649 EF660892 EU304800 GQ847771 HQ316145 JN561683 U31913 U78521

GenPept

AAB39923 AAB59004 AAI04798 AAI04828 ABK60081 ABK60082 ABK60083 ABK60084 ABO16000 ABQ45127 ABQ45128 ABV03523 ABV03524 ABV03525 ABV03526 ABV26697 ACA01869 ACX54433 ADR74098 AEW31446 CAJ85657

RNA Seq Atlas

9049