Homo sapiens Gene: ATL1
Summary
InnateDB Gene IDBG-6063.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATL1
Gene Name atlastin GTPase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198513
Encoded Proteins
atlastin GTPase 1
atlastin GTPase 1
atlastin GTPase 1
atlastin GTPase 1
atlastin GTPase 1
atlastin GTPase 1
atlastin GTPase 1
atlastin GTPase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:50532509-50633068
Strand Forward strand
Band q22.1
Transcripts
ENST00000358385 ENSP00000351155
ENST00000441560 ENSP00000413675
ENST00000556478
ENST00000555960 ENSP00000452506
ENST00000553509 ENSP00000450989
ENST00000554886 ENSP00000452074
ENST00000557735 ENSP00000451015
ENST00000553746
ENST00000555266 ENSP00000450897
ENST00000556067 ENSP00000451100
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0042802 identical protein binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007029 endoplasmic reticulum organization
GO:0007409 axonogenesis
GO:0008219 cell death
GO:0051260 protein homooligomerization
Cellular Component
GO:0000137 Golgi cis cisterna
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0030424 axon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.584905
RefSeq NM_001127713 NM_015915 NM_181598
HUGO
OMIM
CCDS CCDS32077 CCDS9700
HPRD 05918
IMGT
EMBL
GenPept
RNA Seq Atlas