Homo sapiens Gene: CST7
Summary
InnateDB Gene IDBG-60667.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CST7
Gene Name cystatin F (leukocystatin)
Synonyms CMAP;
Species Homo sapiens
Ensembl Gene ENSG00000077984
Encoded Proteins
cystatin F (leukocystatin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:24949230-24959928
Strand Forward strand
Band p11.21
Transcripts
ENST00000480798 ENSP00000420384
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt O76096
TrEMBL
UniProt Splice Variant
Entrez Gene 8530
UniGene
RefSeq NM_003650
HUGO HGNC:2479
OMIM 603253
CCDS CCDS13165
HPRD
IMGT
EMBL AB015225 AB029636 AF031824 AF036342 AJ510167 AJ510168 AJ510169 AJ510170 AL035661 BC015507 BT009825 CR541860 CR541878
GenPept AAC35747 AAC39788 AAH15507 AAP88827 BAA34941 BAB11886 CAB75498 CAD52872 CAG46658 CAG46676
RNA Seq Atlas 8530