Version 5.4
Homo sapiens Gene: NHP2
Summary
InnateDB Gene IDBG-60778.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NHP2
Gene Name NHP2 ribonucleoprotein homolog (yeast)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145912
Encoded Proteins
IDBP-60780
NHP2 ribonucleoprotein homolog (yeast)
IDBP-60782
NHP2 ribonucleoprotein homolog (yeast)
IDBP-481197
NHP2 ribonucleoprotein homolog (yeast)
IDBP-476416
NHP2 ribonucleoprotein homolog (yeast)
IDBP-484714
NHP2 ribonucleoprotein homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:178149460-178153967
Strand Reverse strand
Band q35.3
Transcripts
ENST00000274606 ENSP00000274606
ENST00000314397 ENSP00000366276
ENST00000502263 ENSP00000431126
ENST00000514354 ENSP00000423803
ENST00000511078 ENSP00000423849
ENST00000510363
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0030515 snoRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0031118 rRNA pseudouridine synthesis
Cellular Component
GO:0005634 nucleus
GO:0005732 small nucleolar ribonucleoprotein complex
GO:0005737 cytoplasm
GO:0015030 Cajal body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001056
View Gene Order
ENSBTAG00000006374
Not yet available
Pathways
NETPATH
REACTOME
REACT_7974
Telomere Extension By Telomerase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_7970
Telomere Maintenance pathway
REACT_115566
Cell Cycle pathway
REACT_8030
Extension of Telomeres pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001034833 NM_017838
HUGO
OMIM
CCDS CCDS34308 CCDS4432
HPRD 07570
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca