Homo sapiens Gene: MLLT10
Summary
InnateDB Gene IDBG-60813.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLLT10
Gene Name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
Synonyms AF10;
Species Homo sapiens
Ensembl Gene ENSG00000078403
Encoded Proteins
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:21534165-21743630
Strand Forward strand
Band p12.31
Transcripts
ENST00000377100 ENSP00000366304
ENST00000377091 ENSP00000366295
ENST00000377072 ENSP00000366272
ENST00000377059 ENSP00000366258
ENST00000307729 ENSP00000307411
ENST00000430455 ENSP00000397800
ENST00000438473 ENSP00000408281
ENST00000420525 ENSP00000399883
ENST00000471315
ENST00000495130
ENST00000476557
ENST00000462999
ENST00000480415
ENST00000479634
ENST00000468309
ENST00000621220 ENSP00000484335
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt P55197
TrEMBL B4DVS6 E9PBP4 Q5JT35 Q71UR7
UniProt Splice Variant
Entrez Gene 8028
UniGene Hs.593855 Hs.605494
RefSeq NM_001195626 NM_001195627 NM_001195628 NM_001195630 NM_004641 XM_005252608 XM_005252612 XM_006717509
HUGO HGNC:16063
OMIM 602409
CCDS CCDS55706 CCDS55707 CCDS55708 CCDS7135
HPRD
IMGT
EMBL AF060934 AK301213 AL161799 AL357372 AL358780 AL359697 AY598745 BC080577 BC094844 BC129946 U13948
GenPept AAA79972 AAC16706 AAH80577 AAT47519 BAG62788 CAH73410 CAI13979 CAI13982 CAI13983 CAI39663 CAI41348
RNA Seq Atlas 8028