InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MLLT10

Summary

InnateDB Protein

IDBP-60819.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLLT10

Protein Name

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10

Synonyms

AF10;

Species

Homo sapiens

Ensembl Protein

ENSP00000366272

InnateDB Gene

IDBG-60813 (MLLT10)

Protein Structure

UniProt Annotation

Function

Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. {ECO:0000269PubMed:17868029}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10860745}.

Disease Associations

Note=A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.Note=A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.

Tissue Specificity

Expressed abundantly in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding