Version 5.4
Homo sapiens Gene: ACSS1
Summary
InnateDB Gene IDBG-60920.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACSS1
Gene Name acyl-CoA synthetase short-chain family member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154930
Encoded Proteins
IDBP-60924
acyl-CoA synthetase short-chain family member 1
IDBP-60928
acyl-CoA synthetase short-chain family member 1
IDBP-369517
acyl-CoA synthetase short-chain family member 1
IDBP-587182
acyl-CoA synthetase short-chain family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:25006230-25058980
Strand Reverse strand
Band p11.21
Transcripts
ENST00000323482 ENSP00000316924
ENST00000376726 ENSP00000365916
ENST00000432802 ENSP00000388793
ENST00000484396
ENST00000537502 ENSP00000439304
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003987 acetate-CoA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016208 AMP binding
Biological Process
GO:0006069 ethanol oxidation
GO:0006085 acetyl-CoA biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0019413 acetate biosynthetic process
GO:0019427 acetyl-CoA biosynthetic process from acetate
GO:0019542 propionate biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027452
View Gene Order
ENSBTAG00000004281
Not yet available
Pathways
NETPATH
REACTOME
REACT_34
Ethanol oxidation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00640
Propanoate metabolism pathway
INOH
PID NCI
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
Cross-References
SwissProt
TrEMBL Q5TF43
UniProt Splice Variant
Entrez Gene 84532
UniGene Hs.529353
RefSeq NM_001252675 NM_001252676 NM_001252677 NM_032501
HUGO HGNC:16091
OMIM 614355
CCDS CCDS13167 CCDS58764 CCDS58765
HPRD 12413
IMGT
EMBL AL035661 AL080312
GenPept
RNA Seq Atlas 84532

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca