InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACSS1

Summary

InnateDB Protein

IDBP-60924.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACSS1

Protein Name

acyl-CoA synthetase short-chain family member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000316924

InnateDB Gene

IDBG-60920 (ACSS1)

Protein Structure

UniProt Annotation

Function

Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2). {ECO:0000250, ECO:0000269PubMed:16788062}.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:16788062}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003987	acetate-CoA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016208	AMP binding

Biological Process

GO:0006069	ethanol oxidation
GO:0006085	acetyl-CoA biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0019413	acetate biosynthetic process
GO:0019427	acetyl-CoA biosynthetic process from acetate
GO:0019542	propionate biosynthetic process
GO:0044281	small molecule metabolic process