Version 5.4
Homo sapiens Gene: CLK4
Summary
InnateDB Gene IDBG-61033.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLK4
Gene Name CDC-like kinase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000113240
Encoded Proteins
IDBP-61035
CDC-like kinase 4
IDBP-485115
CDC-like kinase 4
IDBP-475065
CDC-like kinase 4
IDBP-480391
CDC-like kinase 4
IDBP-477442
CDC-like kinase 4
IDBP-807694
CDC-like kinase 4
IDBP-807697
CDC-like kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:178602664-178630615
Strand Reverse strand
Band q35.3
Transcripts
ENST00000316308 ENSP00000316948
ENST00000520878
ENST00000522136 ENSP00000429195
ENST00000519132
ENST00000521621 ENSP00000428651
ENST00000519583
ENST00000522749
ENST00000520199
ENST00000520909
ENST00000520126
ENST00000522556 ENSP00000430216
ENST00000523013
ENST00000520957 ENSP00000430892
ENST00000611575 ENSP00000479788
ENST00000611733 ENSP00000480792
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043484 regulation of RNA splicing
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020385
View Gene Order
ENSBTAG00000019414
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_020666
HUGO
OMIM
CCDS CCDS4437
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca