Homo sapiens Gene: CPLX1
Summary
InnateDB Gene IDBG-6120.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPLX1
Gene Name complexin 1
Synonyms CPX-I; CPX1;
Species Homo sapiens
Ensembl Gene ENSG00000168993
Encoded Proteins
complexin 1
complexin 1
complexin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:784957-826198
Strand Reverse strand
Band p16.3
Transcripts
ENST00000304062 ENSP00000305613
ENST00000505203 ENSP00000425960
ENST00000506404
ENST00000504062 ENSP00000421947
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005326 neurotransmitter transporter activity
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
Biological Process
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0014047 glutamate secretion
GO:0016079 synaptic vesicle exocytosis
GO:0030073 insulin secretion
Cellular Component
GO:0005829 cytosol
GO:0030425 dendrite
GO:0031201 SNARE complex
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0045202 synapse
GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Acetylcholine Neurotransmitter Release Cycle pathway
Neuronal System pathway
Serotonin Neurotransmitter Release Cycle pathway
Norepinephrine Neurotransmitter Release Cycle pathway
GABA synthesis, release, reuptake and degradation pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Release Cycle pathway
Dopamine Neurotransmitter Release Cycle pathway
Glutamate Neurotransmitter Release Cycle pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D6RI11
UniProt Splice Variant
Entrez Gene 10815
UniGene Hs.478930 Hs.593120
RefSeq NM_006651
HUGO HGNC:2309
OMIM 605032
CCDS CCDS46995
HPRD 09233
IMGT
EMBL AC139887
GenPept
RNA Seq Atlas 10815