InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CPLX1

Summary

InnateDB Protein

IDBP-6122.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPLX1

Protein Name

complexin 1

Synonyms

CPX-I; CPX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000305613

InnateDB Gene

IDBG-6120 (CPLX1)

Protein Structure

UniProt Annotation

Function

Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease. {ECO:0000269PubMed:11483314, ECO:0000269PubMed:15526345, ECO:0000269PubMed:9853440}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005326	neurotransmitter transporter activity
GO:0017075	syntaxin-1 binding
GO:0019905	syntaxin binding

Biological Process

GO:0006836	neurotransmitter transport
GO:0006887	exocytosis
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0014047	glutamate secretion
GO:0016079	synaptic vesicle exocytosis
GO:0030073	insulin secretion

Cellular Component

GO:0005829	cytosol
GO:0030425	dendrite
GO:0031201	SNARE complex
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0045202	synapse
GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex