Version 5.4
Homo sapiens Gene: MTMR4
Summary
InnateDB Gene IDBG-61230.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTMR4
Gene Name myotubularin related protein 4
Synonyms FYVE-DSP2; ZFYVE11
Species Homo sapiens
Ensembl Gene ENSG00000108389
Encoded Proteins
IDBP-61232
myotubularin related protein 4
IDBP-759594
IDBP-761077
IDBP-760601
IDBP-759647
IDBP-764307
IDBP-760027
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:58489529-58517905
Strand Reverse strand
Band q22
Transcripts
ENST00000323456 ENSP00000325285
ENST00000583243 ENSP00000464588
ENST00000583656 ENSP00000463479
ENST00000582390 ENSP00000462869
ENST00000580983
ENST00000579925 ENSP00000464067
ENST00000579921 ENSP00000463259
ENST00000578259
ENST00000582663 ENSP00000464247
ENST00000583966
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0016311 dephosphorylation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0031901 early endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018401
View Gene Order
ENSBTAG00000015352
Not yet available
Pathways
NETPATH
REACTOME
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_120756
Synthesis of PIPs at the early endosome membrane pathway
REACT_120918
Synthesis of PIPs at the late endosome membrane pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_111217
Metabolism pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.514373 Hs.593435
RefSeq NM_004687 XM_005257784 XM_005257785 XM_005257786 XM_006722168
HUGO
OMIM
CCDS CCDS11608
HPRD 11945
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca