InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTMR4

Summary

InnateDB Protein

IDBP-61232.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTMR4

Protein Name

myotubularin related protein 4

Synonyms

FYVE-DSP2; ZFYVE11;

Species

Homo sapiens

Ensembl Protein

ENSP00000325285

InnateDB Gene

IDBG-61230 (MTMR4)

Protein Structure

UniProt Annotation

Function

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3). {ECO:0000269PubMed:11302699}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11302699}. Membrane {ECO:0000269PubMed:11302699}; Peripheral membrane protein {ECO:0000269PubMed:11302699}. Note=Localized to perinuclear region.

Disease Associations

Tissue Specificity

Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow. {ECO:0000269PubMed:11302699}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0014894	response to denervation involved in regulation of muscle adaptation
GO:0016311	dephosphorylation
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005829	cytosol
GO:0031901	early endosome membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000306 FYVE zinc finger
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR010569 Myotubularin-like phosphatase domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF01363
PF06602

PRINTS

PIRSF

SMART

SM00064

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NYA4