Version 5.4
Homo sapiens Gene: NIN
Summary
InnateDB Gene IDBG-6133.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NIN
Gene Name ninein (GSK3B interacting protein)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100503
Encoded Proteins
IDBP-6135
ninein (GSK3B interacting protein)
IDBP-6139
ninein (GSK3B interacting protein)
IDBP-6143
ninein (GSK3B interacting protein)
IDBP-6149
ninein (GSK3B interacting protein)
IDBP-6153
ninein (GSK3B interacting protein)
IDBP-368471
ninein (GSK3B interacting protein)
IDBP-368474
ninein (GSK3B interacting protein)
IDBP-592091
ninein (GSK3B interacting protein)
IDBP-600941
ninein (GSK3B interacting protein)
IDBP-806931
ninein (GSK3B interacting protein)
IDBP-588756
ninein (GSK3B interacting protein)
IDBP-583329
ninein (GSK3B interacting protein)
IDBP-586273
ninein (GSK3B interacting protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:50719763-50831121
Strand Reverse strand
Band q22.1
Transcripts
ENST00000245441 ENSP00000245441
ENST00000382043 ENSP00000371474
ENST00000382041 ENSP00000371472
ENST00000389869 ENSP00000374519
ENST00000324330 ENSP00000324210
ENST00000453196 ENSP00000412391
ENST00000453401 ENSP00000398641
ENST00000476352 ENSP00000432924
ENST00000485005 ENSP00000431485
ENST00000480476
ENST00000474937
ENST00000486950 ENSP00000473530
ENST00000486200
ENST00000496749 ENSP00000431826
ENST00000463419
ENST00000530997 ENSP00000436092
ENST00000555984
ENST00000530853 ENSP00000433717
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0034454 microtubule anchoring at centrosome
GO:0051642 centrosome localization
GO:0090222 centrosome-templated microtubule nucleation
Cellular Component
GO:0000922 spindle pole
GO:0005730 nucleolus
GO:0005813 centrosome
GO:0005814 centriole
GO:0005874 microtubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021068
View Gene Order
ENSBTAG00000020281
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.310429 Hs.605176
RefSeq NM_016350 NM_020921 NM_182944 NM_182946 XM_006720160 XM_006720161
HUGO
OMIM
CCDS CCDS32078 CCDS32079
HPRD 09785
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca