InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPP1R15A

Summary

InnateDB Gene

IDBG-61333.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R15A

Gene Name

protein phosphatase 1, regulatory subunit 15A

Synonyms

GADD34;

Species

Homo sapiens

Ensembl Gene

ENSG00000087074

Encoded Proteins

IDBP-61335

protein phosphatase 1, regulatory subunit 15A

IDBP-763751

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:48872392-48876057

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000200453	ENSP00000200453
ENST00000600406	ENSP00000469239

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	37 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0006417	regulation of translation
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0007050	cell cycle arrest
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030968	endoplasmic reticulum unfolded protein response