Version 5.4
Homo sapiens Protein: PPP1R15A
Summary
InnateDB Protein IDBP-61335.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R15A
Protein Name protein phosphatase 1, regulatory subunit 15A
Synonyms GADD34;
Species Homo sapiens
Ensembl Protein ENSP00000200453
InnateDB Gene IDBG-61333 (PPP1R15A)
Protein Structure
UniProt Annotation
Function Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. {ECO:0000269PubMed:11564868, ECO:0000269PubMed:12556489, ECO:0000269PubMed:14635196, ECO:0000269PubMed:14718519, ECO:0000269PubMed:8139541}.
Subcellular Localization Endoplasmic reticulum {ECO:0000269PubMed:12556489}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 37 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0006417 regulation of translation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007050 cell cycle arrest
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030968 endoplasmic reticulum unfolded protein response
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR019523 Protein phosphatase 1, regulatory subunit 15A/B, C-terminal
PFAM PF10488
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75807
PhosphoSite PhosphoSite-O75807
TrEMBL
UniProt Splice Variant
Entrez Gene 23645
UniGene Hs.704109
RefSeq NP_055145
HUGO HGNC:14375
OMIM 611048
CCDS CCDS12738
HPRD 06572
IMGT
EMBL AK001361 BC003067 CH471177 CR457259 U83981
GenPept AAC25631 AAH03067 BAA91649 CAG33540 EAW52409

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca