Version 5.4
Homo sapiens Gene: RUFY1
Summary
InnateDB Gene IDBG-61405.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RUFY1
Gene Name RUN and FYVE domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000176783
Encoded Proteins
IDBP-61407
RUN and FYVE domain containing 1
IDBP-243600
RUN and FYVE domain containing 1
IDBP-243602
RUN and FYVE domain containing 1
IDBP-382523
RUN and FYVE domain containing 1
IDBP-482617
RUN and FYVE domain containing 1
IDBP-480559
RUN and FYVE domain containing 1
IDBP-478798
RUN and FYVE domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:179550558-179610026
Strand Forward strand
Band q35.3
Transcripts
ENST00000319449 ENSP00000325594
ENST00000393448 ENSP00000377094
ENST00000393438 ENSP00000377087
ENST00000437570 ENSP00000390025
ENST00000502984 ENSP00000425533
ENST00000507569
ENST00000503514
ENST00000508609 ENSP00000426701
ENST00000514238
ENST00000502434 ENSP00000426117
ENST00000509797
ENST00000502531
ENST00000503583
ENST00000508797
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0008565 protein transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0030100 regulation of endocytosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031901 early endosome membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020375
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.306769
RefSeq NM_001040451 NM_001040452 NM_025158 XM_005265993 XM_006714922
HUGO
OMIM
CCDS CCDS34312 CCDS4445
HPRD 15282
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca