InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RUFY1

Summary

InnateDB Protein

IDBP-382523.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RUFY1

Protein Name

RUN and FYVE domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000390025

InnateDB Gene

IDBG-61405 (RUFY1)

Protein Structure

UniProt Annotation

Function

Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. {ECO:0000269PubMed:14617813}.

Subcellular Localization

Cytoplasm. Early endosome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Broadly expressed, with highest levels in lung, testis, kidney and brain. {ECO:0000269PubMed:11877430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008289	lipid binding
GO:0046872	metal ion binding

Biological Process

GO:0006897

endocytosis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000306 FYVE zinc finger
IPR001841 Zinc finger, RING-type
IPR004012 RUN
IPR009053 Prefoldin
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related

PFAM

PF01363
PF13639
PF14634
PF02759

PRINTS

PIRSF

SMART

SM00064
SM00184
SM00593

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96T51