InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VCP

Summary

InnateDB Gene

IDBG-61415.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VCP

Gene Name

valosin containing protein

Synonyms

ALS14; HEL-220; HEL-S-70; IBMPFD; IBMPFD1; p97; TERA

Species

Homo sapiens

Ensembl Gene

ENSG00000165280

Encoded Proteins

IDBP-61419

valosin containing protein

IDBP-368067

valosin containing protein

IDBP-368068

valosin containing protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:35056064-35073249

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000358901	ENSP00000351777
ENST00000448530	ENSP00000392088
ENST00000417448	ENSP00000399456
ENST00000493886
ENST00000466100
ENST00000479300
ENST00000480327

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 644 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	644 [view]
Protein-Protein	640 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008289	lipid binding
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0016887	ATPase activity
GO:0019903	protein phosphatase binding
GO:0019904	protein domain specific binding
GO:0031593	polyubiquitin binding
GO:0032403	protein complex binding
GO:0035800	deubiquitinase activator activity
GO:0042802	identical protein binding
GO:0043531	ADP binding
GO:0044822	poly(A) RNA binding
GO:1990381	ubiquitin-specific protease binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0016567	protein ubiquitination
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019985	translesion synthesis
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0030970	retrograde protein transport, ER to cytosol
GO:0031334	positive regulation of protein complex assembly
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034214	protein hexamerization
GO:0042981	regulation of apoptotic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045184	establishment of protein localization
GO:0045732	positive regulation of protein catabolic process
GO:0051260	protein homooligomerization
GO:0070842	aggresome assembly
GO:1903006	positive regulation of protein K63-linked deubiquitination
GO:1903007	positive regulation of Lys63-specific deubiquitinase activity

Cellular Component

GO:0000502	proteasome complex
GO:0000836	Hrd1p ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0035861	site of double-strand break
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome