Homo sapiens Gene: VCP
Summary
InnateDB Gene IDBG-61415.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VCP
Gene Name valosin containing protein
Synonyms ALS14; HEL-220; HEL-S-70; IBMPFD; IBMPFD1; p97; TERA;
Species Homo sapiens
Ensembl Gene ENSG00000165280
Encoded Proteins
valosin containing protein
valosin containing protein
valosin containing protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:35056064-35073249
Strand Reverse strand
Band p13.3
Transcripts
ENST00000358901 ENSP00000351777
ENST00000448530 ENSP00000392088
ENST00000417448 ENSP00000399456
ENST00000493886
ENST00000466100
ENST00000479300
ENST00000480327
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 644 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 644 [view]
Protein-Protein 640 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATPase activity
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0031593 polyubiquitin binding
GO:0032403 protein complex binding
GO:0035800 deubiquitinase activator activity
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0044822 poly(A) RNA binding
GO:1990381 ubiquitin-specific protease binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0016567 protein ubiquitination
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019985 translesion synthesis
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0030970 retrograde protein transport, ER to cytosol
GO:0031334 positive regulation of protein complex assembly
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034214 protein hexamerization
GO:0042981 regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045184 establishment of protein localization
GO:0045732 positive regulation of protein catabolic process
GO:0051260 protein homooligomerization
GO:0070842 aggresome assembly
GO:1903006 positive regulation of protein K63-linked deubiquitination
GO:1903007 positive regulation of Lys63-specific deubiquitinase activity
Cellular Component
GO:0000502 proteasome complex
GO:0000836 Hrd1p ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0035861 site of double-strand break
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
IL9 pathway
REACTOME
Cellular responses to stress pathway
Processing-defective Hh variants abrogate ligand secretion pathway
Signaling by Hedgehog pathway
Signal Transduction pathway
Hh ligand biogenesis disease pathway
Hedgehog ligand biogenesis pathway
Cellular response to heat stress pathway
HSF1 activation pathway
Disease pathway
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.617372
RefSeq NM_007126
HUGO
OMIM
CCDS CCDS6573
HPRD 03013
IMGT
EMBL
GenPept
RNA Seq Atlas