Homo sapiens Gene: ARAF
Summary
InnateDB Gene IDBG-61504.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARAF
Gene Name v-raf murine sarcoma 3611 viral oncogene homolog
Synonyms A-RAF; ARAF1; PKS2; RAFA1;
Species Homo sapiens
Ensembl Gene ENSG00000078061
Encoded Proteins
v-raf murine sarcoma 3611 viral oncogene homolog
v-raf murine sarcoma 3611 viral oncogene homolog
v-raf murine sarcoma 3611 viral oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:47561100-47571920
Strand Forward strand
Band p11.3
Transcripts
ENST00000377045 ENSP00000366244
ENST00000290277 ENSP00000290277
ENST00000377039 ENSP00000366238
ENST00000489496
ENST00000469505
ENST00000470206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 71 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0032006 regulation of TOR signaling
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
ErbB signaling pathway pathway
Vascular smooth muscle contraction pathway
Natural killer cell mediated cytotoxicity pathway
Long-term potentiation pathway
Long-term depression pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
INOH
IGF1 signaling pathway pathway
NGF signaling pathway pathway
GPCR signaling pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
Mapkinase signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.446641
RefSeq NM_001256196 NM_001256197 NM_001654 XM_006724529
HUGO
OMIM
CCDS CCDS35232 CCDS59164 CCDS75970
HPRD 02405
IMGT
EMBL
GenPept
RNA Seq Atlas