InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Araf

Summary

InnateDB Gene

IDBG-135379.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Araf

Gene Name

v-raf murine sarcoma 3611 viral oncogene homolog

Synonyms

1200013E08Rik; A-Raf; Araf1; AW495444

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001127

Encoded Proteins

IDBP-135381

v-raf murine sarcoma 3611 viral oncogene homolog

IDBP-401413

v-raf murine sarcoma 3611 viral oncogene homolog

IDBP-401412

v-raf murine sarcoma 3611 viral oncogene homolog

IDBP-542155

v-raf murine sarcoma 3611 viral oncogene homolog

IDBP-534544

v-raf murine sarcoma 3611 viral oncogene homolog

IDBP-538919

v-raf murine sarcoma 3611 viral oncogene homolog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078061:
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:20797814-20860519

Strand

Forward strand

Band

A1.3

Transcripts

ENSMUST00000001155	ENSMUSP00000001155
ENSMUST00000122312	ENSMUSP00000112521
ENSMUST00000120356	ENSMUSP00000112513
ENSMUST00000136451	ENSMUSP00000115793
ENSMUST00000152955
ENSMUST00000148032
ENSMUST00000150190
ENSMUST00000122850	ENSMUSP00000114846
ENSMUST00000123219
ENSMUST00000128250	ENSMUSP00000119544

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0032006	regulation of TOR signaling
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005739

mitochondrion

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000078061

View Gene Order

ENSBTAG00000005039

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05213

Endometrial cancer pathway

mmu05219

Bladder cancer pathway

mmu05211

Renal cell carcinoma pathway

mmu04012

ErbB signaling pathway pathway

mmu04910

Insulin signaling pathway pathway

mmu05221

Acute myeloid leukemia pathway

mmu05210

Colorectal cancer pathway

mmu05218

Melanoma pathway

mmu04650

Natural killer cell mediated cytotoxicity pathway

mmu04810

Regulation of actin cytoskeleton pathway

mmu04720

Long-term potentiation pathway

mmu05214

Glioma pathway

mmu05215

Prostate cancer pathway

mmu04730

Long-term depression pathway

mmu05220

Chronic myeloid leukemia pathway

mmu05223

Non-small cell lung cancer pathway

mmu05212

Pancreatic cancer pathway

mmu04270

Vascular smooth muscle contraction pathway

mmu05200

Pathways in cancer pathway

mmu04914

Progesterone-mediated oocyte maturation pathway

mmu05160

Hepatitis C pathway

INOH