InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GAL

Summary

InnateDB Gene

IDBG-61517.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAL

Gene Name

galanin/GMAP prepropeptide

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000069482

Encoded Proteins

IDBP-61519

galanin prepropeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions (Mechenthaler, 2008 [PubMed 18500643]).[supplied by OMIM, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:68683779-68691175

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000265643	ENSP00000265643
ENST00000538401

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity
GO:0005515	protein binding
GO:0031764	type 1 galanin receptor binding
GO:0031765	type 2 galanin receptor binding
GO:0031766	type 3 galanin receptor binding

Biological Process

GO:0006954	inflammatory response
GO:0007218	neuropeptide signaling pathway
GO:0007399	nervous system development
GO:0007631	feeding behavior
GO:0008285	negative regulation of cell proliferation
GO:0010737	protein kinase A signaling
GO:0019933	cAMP-mediated signaling
GO:0030073	insulin secretion
GO:0031943	regulation of glucocorticoid metabolic process
GO:0032868	response to insulin
GO:0035902	response to immobilization stress
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043627	response to estrogen
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050672	negative regulation of lymphocyte proliferation
GO:0051464	positive regulation of cortisol secretion
GO:0051795	positive regulation of catagen
GO:1902608	positive regulation of large conductance calcium-activated potassium channel activity
GO:1902891	negative regulation of root hair elongation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0030141	secretory granule
GO:0043025	neuronal cell body