Homo sapiens Gene: GAL
Summary
InnateDB Gene IDBG-61517.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAL
Gene Name galanin/GMAP prepropeptide
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000069482
Encoded Proteins
galanin prepropeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions (Mechenthaler, 2008 [PubMed 18500643]).[supplied by OMIM, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:68683779-68691175
Strand Forward strand
Band q13.2
Transcripts
ENST00000265643 ENSP00000265643
ENST00000538401
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
GO:0031764 type 1 galanin receptor binding
GO:0031765 type 2 galanin receptor binding
GO:0031766 type 3 galanin receptor binding
Biological Process
GO:0006954 inflammatory response
GO:0007218 neuropeptide signaling pathway
GO:0007399 nervous system development
GO:0007631 feeding behavior
GO:0008285 negative regulation of cell proliferation
GO:0010737 protein kinase A signaling
GO:0019933 cAMP-mediated signaling
GO:0030073 insulin secretion
GO:0031943 regulation of glucocorticoid metabolic process
GO:0032868 response to insulin
GO:0035902 response to immobilization stress
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050672 negative regulation of lymphocyte proliferation
GO:0051464 positive regulation of cortisol secretion
GO:0051795 positive regulation of catagen
GO:1902608 positive regulation of large conductance calcium-activated potassium channel activity
GO:1902891 negative regulation of root hair elongation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0030141 secretory granule
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P22466
TrEMBL
UniProt Splice Variant
Entrez Gene 51083
UniGene Hs.616268
RefSeq NM_015973 XM_006718580
HUGO HGNC:4114
OMIM 137035
CCDS CCDS8183
HPRD 00658
IMGT
EMBL BC030241 L11144 M77140
GenPept AAA18248 AAA60178 AAH30241
RNA Seq Atlas 51083