Homo sapiens Gene: FTL
Summary
InnateDB Gene IDBG-61607.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FTL
Gene Name ferritin, light polypeptide
Synonyms LFTD; NBIA3;
Species Homo sapiens
Ensembl Gene ENSG00000087086
Encoded Proteins
ferritin, light polypeptide
ferritin, light polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:48965301-48966878
Strand Forward strand
Band q13.33
Transcripts
ENST00000331825 ENSP00000366525
ENST00000622577 ENSP00000484043
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 40 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008199 ferric iron binding
GO:0042802 identical protein binding
Biological Process
GO:0006826 iron ion transport
GO:0006879 cellular iron ion homeostasis
GO:0006892 post-Golgi vesicle-mediated transport
GO:0008219 cell death
GO:0055072 iron ion homeostasis
GO:0055085 transmembrane transport
GO:0061024 membrane organization
Cellular Component
GO:0005829 cytosol
GO:0008043 intracellular ferritin complex
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
trans-Golgi Network Vesicle Budding pathway
Iron uptake and transport pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Scavenging by Class A Receptors pathway
Clathrin derived vesicle budding pathway
Golgi Associated Vesicle Biogenesis pathway
Membrane Trafficking pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000146
HUGO
OMIM
CCDS CCDS33070
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas