Version 5.4
| Homo sapiens Gene: CFP | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-61793.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CFP | ||||||||||||||||||
| Gene Name | complement factor properdin | ||||||||||||||||||
| Synonyms | BFD; PFC; PFD; PROPERDIN | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000126759 | ||||||||||||||||||
| Encoded Proteins |
complement factor properdin
complement factor properdin
complement factor properdin
complement factor properdin
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
CFP binds to early apoptotic T cells and initiates complement activation, leading to C3B opsonization and ingestion by phagocytic cells.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||
| Summary |
[Mus musculus] Cfp plays a role in intestinal homeostasis in response to an infectious challenge to activate Hc (C5a), which in turn provides protection through Il6 expression by the epithelium.
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome X:47624213-47630305 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p11.23 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Activation of C3 and C5 pathway
Alternative complement activation pathway
Initial triggering of complement pathway
Regulation of Complement cascade pathway
Post-translational protein modification pathway
Innate Immune System pathway
O-linked glycosylation pathway
Metabolism of proteins pathway
Immune System pathway
Complement cascade pathway
O-glycosylation of TSR domain-containing proteins pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.53155 | ||||||||||||||||||
| RefSeq | NM_001145252 NM_002621 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS14282 | ||||||||||||||||||
| HPRD | 02308 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||