InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CFP

Summary

InnateDB Protein

IDBP-61797.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CFP

Protein Name

complement factor properdin

Synonyms

BFD; PFC; PFD; PROPERDIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000247153

InnateDB Gene

IDBG-61793 (CFP)

Protein Structure

UniProt Annotation

Function

A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. {ECO:0000269PubMed:20382442}.

Subcellular Localization

Secreted.

Disease Associations

Properdin deficiency (PFD) [MIM:312060]: Results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III). {ECO:0000269PubMed:10909851, ECO:0000269PubMed:8871668, ECO:0000269PubMed:9710744}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006955	immune response
GO:0006956	complement activation
GO:0006957	complement activation, alternative pathway
GO:0030449	regulation of complement activation
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)