InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DHX36

Summary

InnateDB Gene

IDBG-62011.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX36

Gene Name

DEAH (Asp-Glu-Ala-His) box polypeptide 36

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000174953

Encoded Proteins

IDBP-62013

DEAH (Asp-Glu-Ala-His) box polypeptide 36

IDBP-62015

DEAH (Asp-Glu-Ala-His) box polypeptide 36

IDBP-483239

DEAH (Asp-Glu-Ala-His) box polypeptide 36

IDBP-476957

DEAH (Asp-Glu-Ala-His) box polypeptide 36

IDBP-475352

DEAH (Asp-Glu-Ala-His) box polypeptide 36

IDBP-481187

DEAH (Asp-Glu-Ala-His) box polypeptide 36

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20696886

DHX36 interacts with CpG-A and is associated with IFN-alpha production and IRF7 nuclear translocation upon CpG-A stimulation. DHX36 localizes within the cytosol and directly binds to the TLR domain of MYD88.

PMID 21703541

DHX36 is a component of a cytosolic viral sensor and is recruited to a complex consisting of DDX1, DDX21 and TICAM1, which triggers type I interferon and cytokine response to dsRNA. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21703541

[Mus musculus] Dhx36 is a component of a cytosolic viral sensor and is recruited to a complex consisting of Ddx1, Ddx21 and Ticam1, which triggers type I interferon and cytokine response to dsRNA.

Entrez Gene

Summary

This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:154272546-154324497

Strand

Reverse strand

Band

q25.2

Transcripts

ENST00000329463	ENSP00000330113
ENST00000308361	ENSP00000309296
ENST00000496811	ENSP00000417078
ENST00000495598
ENST00000477549
ENST00000479934	ENSP00000418756
ENST00000481941	ENSP00000419862
ENST00000460695
ENST00000469977	ENSP00000419761
ENST00000481332
ENST00000460875
ENST00000462464
ENST00000491011

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0002151	G-quadruplex RNA binding
GO:0003676	nucleic acid binding
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008094	DNA-dependent ATPase activity
GO:0042826	histone deacetylase binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0051880	G-quadruplex DNA binding

Biological Process

GO:0001503	ossification
GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0008152	metabolic process
GO:0009615	response to virus
GO:0010501	RNA secondary structure unwinding
GO:0032206	positive regulation of telomere maintenance
GO:0032481	positive regulation of type I interferon production
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter