Version 5.4
Bos taurus Gene: NPM1
Summary
InnateDB Gene IDBG-628420.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPM1
Gene Name nucleophosmin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015316
Encoded Proteins
IDBP-679835
nucleophosmin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181163:
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:3111198-3123860
Strand Forward strand
Band
Transcripts
ENSBTAT00000020363 ENSBTAP00000020363
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 186 interaction(s) predicted by orthology.
Predicted by orthology
Total 186 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
Biological Process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000181163
View Gene Order
ENSMUSG00000057113
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_9395
Nuclear import of Rev protein pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_115566
Cell Cycle pathway
REACT_6185
HIV Infection pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_6916
Interactions of Rev with host cellular proteins pathway
REACT_116125
Disease pathway
REACT_233453
Chromosome Maintenance pathway
REACT_188804
Cell Cycle pathway
REACT_198595
Nucleosome assembly pathway
REACT_198597
Deposition of new CENPA-containing nucleosomes at the centromere pathway
KEGG
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
hif1_tfpathway
HIF-1-alpha transcription factor network
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt
TrEMBL E3SAZ8 F1MTV9
UniProt Splice Variant
Entrez Gene 614028
UniGene Bt.3599 Bt.61659 Bt.71659
RefSeq NM_001035441
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02049872 GQ153529
GenPept ACY72373
RNA Seq Atlas 614028

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca