Version 5.4
| Bos taurus Gene: IRF2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-628515.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | IRF2 | ||||||||
| Gene Name | interferon regulatory factor 2 | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000010002 | ||||||||
| Encoded Proteins |
Uncharacterized protein
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] IRF2 is a transcriptional repressor that functions by competing with the transcriptional activator IRF1 and has also been shown to functions as a transcriptional activator for several genes. IRF2 transcriptional activity is regulated by sumoylation whereby covalent modification of IRF2 by SUMO1 results in enhanced transcriptional repression activity on IRF1.
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168310:
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 27:13909933-13950319 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
Method
Confidence
Comments
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
TRAF6 mediated IRF7 activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Interferon Signaling pathway
Immune System pathway
Interferon gamma signaling pathway
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
Innate Immune System pathway
Hemostasis pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
TRAF6 mediated IRF7 activation pathway
Factors involved in megakaryocyte development and platelet production pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID BIOCARTA |
The information processing pathway at the ifn beta enhancer
[Biocarta view]
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| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Bt.15989 | ||||||||
| RefSeq | NM_001205793 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||
| Transcript Frequencies | |||||||||
| Tag Count based mRNA-Abundances across 87 different Tissues (TPM).
Based on Data from Bovine Gene Atlas |
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