Homo sapiens Gene: IRF2
Summary
InnateDB Gene IDBG-46310.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRF2
Gene Name interferon regulatory factor 2
Synonyms IRF-2;
Species Homo sapiens
Ensembl Gene ENSG00000168310
Encoded Proteins
interferon regulatory factor 2
interferon regulatory factor 2
interferon regulatory factor 2
interferon regulatory factor 2
interferon regulatory factor 2
interferon regulatory factor 2
interferon regulatory factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IRF2 is a transcriptional repressor that functions by competing with the transcriptional activator IRF1 and has also been shown to functions as a transcriptional activator for several genes. IRF2 transcriptional activity is regulated by sumoylation whereby covalent modification of IRF2 by SUMO1 results in enhanced transcriptional repression activity on IRF1.
Entrez Gene
Summary IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:184387713-184474580
Strand Reverse strand
Band q35.1
Transcripts
ENST00000393593 ENSP00000377218
ENST00000505067 ENSP00000421927
ENST00000502750 ENSP00000423074
ENST00000507523 ENSP00000427204
ENST00000512020
ENST00000510814 ENSP00000424552
ENST00000506230 ENSP00000422860
ENST00000509274 ENSP00000425037
ENST00000504340
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 89 [view]
Protein-Protein 46 [view]
Protein-DNA 43 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
TRAF6 mediated IRF7 activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Interferon Signaling pathway
Immune System pathway
Interferon gamma signaling pathway
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
The information processing pathway at the ifn beta enhancer [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.627315
RefSeq NM_002199 XM_005262984 XM_005262986
HUGO
OMIM
CCDS CCDS3835
HPRD 00962
IMGT
EMBL
GenPept
RNA Seq Atlas