InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IRF2

Summary

InnateDB Gene

IDBG-46310.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF2

Gene Name

interferon regulatory factor 2

Synonyms

IRF-2

Species

Homo sapiens

Ensembl Gene

ENSG00000168310

Encoded Proteins

IDBP-243306

interferon regulatory factor 2

IDBP-482166

interferon regulatory factor 2

IDBP-477940

interferon regulatory factor 2

IDBP-479122

interferon regulatory factor 2

IDBP-474864

interferon regulatory factor 2

IDBP-475929

interferon regulatory factor 2

IDBP-478877

interferon regulatory factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18514056

IRF2 is a transcriptional repressor that functions by competing with the transcriptional activator IRF1 and has also been shown to functions as a transcriptional activator for several genes. IRF2 transcriptional activity is regulated by sumoylation whereby covalent modification of IRF2 by SUMO1 results in enhanced transcriptional repression activity on IRF1.

Entrez Gene

Summary

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:184387713-184474580

Strand

Reverse strand

Band

q35.1

Transcripts

ENST00000393593	ENSP00000377218
ENST00000505067	ENSP00000421927
ENST00000502750	ENSP00000423074
ENST00000507523	ENSP00000427204
ENST00000512020
ENST00000510814	ENSP00000424552
ENST00000506230	ENSP00000422860
ENST00000509274	ENSP00000425037
ENST00000504340

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	46 [view]
Protein-DNA	43 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway