InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.36413

Summary

InnateDB Gene

IDBG-628663.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.36413

Gene Name

protein Mdm4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006255

Encoded Proteins

IDBP-680034

protein Mdm4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198625:
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter\'s degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:2066067-2103323

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008209

ENSBTAP00000008209

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0042177	negative regulation of protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0045023	G0 to G1 transition
GO:0050821	protein stabilization
GO:0071157	negative regulation of cell cycle arrest
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000198625

View Gene Order

ENSMUSG00000054387

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04115

p53 signaling pathway pathway

mmu04115

p53 signaling pathway pathway

INOH

PID NCI

p53regulationpathway

p53 pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.104462 Bt.36413

RefSeq

NM_001046169 XM_005206447 XM_005216668 XM_005216669

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas