Homo sapiens Gene: MDM4 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-106054.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | MDM4 | ||||||||||||||||||||||||
Gene Name | Mdm4 p53 binding protein homolog (mouse) | ||||||||||||||||||||||||
Synonyms | HDMX; MDMX; MRP1 | ||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000198625 | ||||||||||||||||||||||||
Encoded Proteins |
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
MDM4, p53 regulator
MDM4, p53 regulator
MDM4, p53 regulator
MDM4, p53 regulator
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter\'s degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 1:204516379-204558120 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | q32.1 | ||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||||
KEGG |
p53 signaling pathway pathway
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INOH | |||||||||||||||||||||||||
PID NCI |
p53 pathway
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Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
UniGene | Hs.497492 Hs.603945 Hs.623426 Hs.625091 Hs.658187 | ||||||||||||||||||||||||
RefSeq | NM_001204171 NM_001204172 NM_001278516 NM_001278517 NM_001278518 NM_001278519 NM_002393 XM_006711328 XM_006711329 | ||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS1447 CCDS55674 CCDS55675 CCDS60396 CCDS73007 CCDS73008 CCDS73009 | ||||||||||||||||||||||||
HPRD | 04082 | ||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||