Homo sapiens Gene: MDM4
Summary
InnateDB Gene IDBG-106054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MDM4
Gene Name Mdm4 p53 binding protein homolog (mouse)
Synonyms HDMX; MDMX; MRP1;
Species Homo sapiens
Ensembl Gene ENSG00000198625
Encoded Proteins
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
MDM4, p53 regulator
MDM4, p53 regulator
MDM4, p53 regulator
MDM4, p53 regulator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter\'s degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:204516379-204558120
Strand Forward strand
Band q32.1
Transcripts
ENST00000367183 ENSP00000356151
ENST00000367182 ENSP00000356150
ENST00000367180 ENSP00000356148
ENST00000367179 ENSP00000356147
ENST00000391947 ENSP00000375811
ENST00000454264 ENSP00000396840
ENST00000444261 ENSP00000395254
ENST00000507825 ENSP00000443816
ENST00000470797
ENST00000463049
ENST00000470908
ENST00000471783
ENST00000462012
ENST00000616250 ENSP00000478581
ENST00000612738 ENSP00000478080
ENST00000614459 ENSP00000482388
ENST00000621032 ENSP00000482479
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 80 [view]
Protein-Protein 79 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006461 protein complex assembly
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0042177 negative regulation of protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0045023 G0 to G1 transition
GO:0050821 protein stabilization
GO:0071157 negative regulation of cell cycle arrest
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
p53 signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
p53 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.497492 Hs.603945 Hs.623426 Hs.625091 Hs.658187
RefSeq NM_001204171 NM_001204172 NM_001278516 NM_001278517 NM_001278518 NM_001278519 NM_002393 XM_006711328 XM_006711329
HUGO
OMIM
CCDS CCDS1447 CCDS55674 CCDS55675 CCDS60396 CCDS73007 CCDS73008 CCDS73009
HPRD 04082
IMGT
EMBL
GenPept
RNA Seq Atlas