InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DDC

Summary

InnateDB Gene

IDBG-628768.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDC

Gene Name

aromatic-L-amino-acid decarboxylase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020869

Encoded Proteins

IDBP-680158

aromatic-L-amino-acid decarboxylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132437:
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:5253835-5347715

Strand

Forward strand

Band

Transcripts

ENSBTAT00000054605

ENSBTAP00000051814

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004058	aromatic-L-amino-acid decarboxylase activity
GO:0005515	protein binding
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding