Bos taurus Gene: ST8SIA2
Summary
InnateDB Gene IDBG-628781.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST8SIA2
Gene Name alpha-2,8-sialyltransferase 8B precursor
Synonyms SIAT 8B;
Species Bos taurus
Ensembl Gene ENSBTAG00000017896
Encoded Proteins
alpha-2,8-sialyltransferase 8B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140557:
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:14879467-14949980
Strand Reverse strand
Band
Transcripts
ENSBTAT00000023784 ENSBTAP00000023784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373 sialyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
Biological Process
GO:0001574 ganglioside biosynthetic process
GO:0006486 protein glycosylation
GO:0006491 N-glycan processing
GO:0009311 oligosaccharide metabolic process
GO:0097503 sialylation
Cellular Component
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
GO:0055037 recycling endosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Post-translational protein modification pathway
N-Glycan antennae elongation pathway
NCAM signaling for neurite out-growth pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
NCAM1 interactions pathway
Synthesis of substrates in N-glycan biosythesis pathway
Axon guidance pathway
Asparagine N-linked glycosylation pathway
Sialic acid metabolism pathway
Metabolism of proteins pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Transport to the Golgi and subsequent modification pathway
N-Glycan antennae elongation pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
Transport to the Golgi and subsequent modification pathway
Synthesis of substrates in N-glycan biosythesis pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
NCAM1 interactions pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Axon guidance pathway
Asparagine N-linked glycosylation pathway
Developmental Biology pathway
NCAM signaling for neurite out-growth pathway
Sialic acid metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL A2BCP4
UniProt Splice Variant
Entrez Gene 540267
UniGene Bt.88423
RefSeq NM_001098113 XM_005221765
HUGO HGNC:10870
OMIM
CCDS
HPRD
IMGT
EMBL AM422133 DAAA02051970 DAAA02051971 DAAA02051972
GenPept CAM12262
RNA Seq Atlas 540267
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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