Mus musculus Gene: St8sia2
Summary
InnateDB Gene IDBG-192862.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol St8sia2
Gene Name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Synonyms AI323367; Siat8b; ST8SiaII; STX;
Species Mus musculus
Ensembl Gene ENSMUSG00000025789
Encoded Proteins
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140557:
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:73939119-74013682
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000026896 ENSMUSP00000026896
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0001574 ganglioside biosynthetic process
GO:0006486 protein glycosylation
GO:0006491 N-glycan processing
GO:0009311 oligosaccharide metabolic process
GO:0097503 sialylation
Cellular Component
GO:0005769 early endosome
GO:0030173 integral component of Golgi membrane
GO:0055037 recycling endosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
N-Glycan antennae elongation pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
Transport to the Golgi and subsequent modification pathway
Synthesis of substrates in N-glycan biosythesis pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
NCAM1 interactions pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Axon guidance pathway
Asparagine N-linked glycosylation pathway
Developmental Biology pathway
NCAM signaling for neurite out-growth pathway
Sialic acid metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Post-translational protein modification pathway
N-Glycan antennae elongation pathway
NCAM signaling for neurite out-growth pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
NCAM1 interactions pathway
Synthesis of substrates in N-glycan biosythesis pathway
Axon guidance pathway
Asparagine N-linked glycosylation pathway
Sialic acid metabolism pathway
Metabolism of proteins pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Transport to the Golgi and subsequent modification pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O35696
TrEMBL
UniProt Splice Variant
Entrez Gene 20450
UniGene Mm.413695 Mm.4954
RefSeq NM_009181 XM_006540731
OMIM
CCDS CCDS21365
HPRD
IMGT
MGI ID MGI:106020
MGI Symbol St8sia2
EMBL BC096546 CH466543 X83562 X99646 X99647 X99648 X99649 X99650 X99651
GenPept AAH96546 CAA58548 CAA67965 EDL07123
RNA Seq Atlas 20450