InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.93003

Summary

InnateDB Gene

IDBG-628786.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.93003

Gene Name

DNA-binding protein Ikaros

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014016

Encoded Proteins

IDBP-680164

DNA-binding protein Ikaros

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185811:
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2011]
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:5424474-5494384

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000018632

ENSBTAP00000018632

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001779	natural killer cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0030097	hemopoiesis
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030900	forebrain development
GO:0040018	positive regulation of multicellular organism growth
GO:0045660	positive regulation of neutrophil differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048535	lymph node development
GO:0048538	thymus development
GO:0048541	Peyer's patch development
GO:0048732	gland development
GO:0051138	positive regulation of NK T cell differentiation
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0005634	nucleus
GO:0005721	centromeric heterochromatin

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000185811

View Gene Order

ENSMUSG00000018654

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

nfat_tfpathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Cross-References

SwissProt

TrEMBL

E1BAW6

UniProt Splice Variant

Entrez Gene

541154

UniGene

Bt.93003

RefSeq

NM_001105257 XM_005205098 XM_005205100 XM_005205101 XM_005205102 XM_005205103

HUGO

HGNC:13176

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02009678 DAAA02009679

GenPept

RNA Seq Atlas

541154