Mus musculus Gene: Ikzf1
Summary
InnateDB Gene IDBG-150234.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ikzf1
Gene Name IKAROS family zinc finger 1
Synonyms 5832432G11Rik; hlk-1; Ikaros; LyF-1; mKIAA4227; Zfpn1a1; Znfn1a1;
Species Mus musculus
Ensembl Gene ENSMUSG00000018654
Encoded Proteins
IKAROS family zinc finger 1
IKAROS family zinc finger 1
IKAROS family zinc finger 1
IKAROS family zinc finger 1
IKAROS family zinc finger 1
IKAROS family zinc finger 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to a family of transcription factors that are characterized by a set of four DNA-binding zinc fingers at the N-terminus and two C-terminal zinc fingers involved in protein dimerization. It is regulated by both epigenetic and transcription factors. This protein is a transcriptional regulator of hematopoietic cell development and homeostasis. In addition, it is required to confer temporal competence to retinal progenitor cells during embryogenesis, demonstrating an essential function in nervous system development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:11685003-11772926
Strand Forward strand
Band A1
Transcripts
ENSMUST00000065433 ENSMUSP00000067372
ENSMUST00000076700 ENSMUSP00000075992
ENSMUST00000018798 ENSMUSP00000018798
ENSMUST00000048122 ENSMUSP00000046974
ENSMUST00000126058 ENSMUSP00000119960
ENSMUST00000141436 ENSMUSP00000117958
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 19 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001779 natural killer cell differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0030097 hemopoiesis
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030900 forebrain development
GO:0040018 positive regulation of multicellular organism growth
GO:0045660 positive regulation of neutrophil differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048535 lymph node development
GO:0048538 thymus development
GO:0048541 Peyer's patch development
GO:0048732 gland development
GO:0051138 positive regulation of NK T cell differentiation
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005721 centromeric heterochromatin
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Cross-References
SwissProt
TrEMBL G5E8H3 Q571F4 Q5GGW4
UniProt Splice Variant
Entrez Gene 22778
UniGene Mm.103545
RefSeq NM_001025597 XM_006514669 XM_006514670 XM_006514671 XM_006514673 XM_006514674 XM_006514675 XM_006514676 XM_006514680 XM_006514682 XM_006514683 NM_009578 XM_006514685
OMIM
CCDS CCDS24436 CCDS24437
HPRD
IMGT
MGI ID MGI:1342540
MGI Symbol Ikzf1
EMBL AK220235 AL596450 AY536270 CH466574
GenPept AAT09852 BAD90160 EDL40638 EDL40639
RNA Seq Atlas 22778