Version 5.4
Mus musculus Gene: Ikzf1
Summary
InnateDB Gene IDBG-150234.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ikzf1
Gene Name IKAROS family zinc finger 1
Synonyms 5832432G11Rik; hlk-1; Ikaros; LyF-1; mKIAA4227; Zfpn1a1; Znfn1a1
Species Mus musculus
Ensembl Gene ENSMUSG00000018654
Encoded Proteins
IDBP-150236
IKAROS family zinc finger 1
IDBP-150238
IKAROS family zinc finger 1
IDBP-150240
IKAROS family zinc finger 1
IDBP-150248
IKAROS family zinc finger 1
IDBP-542554
IKAROS family zinc finger 1
IDBP-542826
IKAROS family zinc finger 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to a family of transcription factors that are characterized by a set of four DNA-binding zinc fingers at the N-terminus and two C-terminal zinc fingers involved in protein dimerization. It is regulated by both epigenetic and transcription factors. This protein is a transcriptional regulator of hematopoietic cell development and homeostasis. In addition, it is required to confer temporal competence to retinal progenitor cells during embryogenesis, demonstrating an essential function in nervous system development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:11685003-11772926
Strand Forward strand
Band A1
Transcripts
ENSMUST00000065433 ENSMUSP00000067372
ENSMUST00000076700 ENSMUSP00000075992
ENSMUST00000018798 ENSMUSP00000018798
ENSMUST00000048122 ENSMUSP00000046974
ENSMUST00000126058 ENSMUSP00000119960
ENSMUST00000141436 ENSMUSP00000117958
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 19 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001779 natural killer cell differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0030097 hemopoiesis
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030900 forebrain development
GO:0040018 positive regulation of multicellular organism growth
GO:0045660 positive regulation of neutrophil differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048535 lymph node development
GO:0048538 thymus development
GO:0048541 Peyer's patch development
GO:0048732 gland development
GO:0051138 positive regulation of NK T cell differentiation
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005721 centromeric heterochromatin
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185811
View Gene Order
ENSBTAG00000014016
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Cross-References
SwissProt
TrEMBL Q5GGW4 Q5SWT7 Q5SWU0
UniProt Splice Variant
Entrez Gene 22778
UniGene Mm.103545
RefSeq NM_009578 XM_006514685 NM_001025597 XM_006514669 XM_006514670 XM_006514671 XM_006514673 XM_006514674 XM_006514675 XM_006514676 XM_006514680 XM_006514682 XM_006514683
OMIM
CCDS CCDS24437 CCDS24436
HPRD
IMGT
MGI ID MGI:1342540
MGI Symbol Ikzf1
EMBL AL596450 AY536270 BC138789 CH466574
GenPept AAI38790 AAT09852 EDL40640 EDL40643
RNA Seq Atlas 22778

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca