InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL13A

Summary

InnateDB Gene

IDBG-62892.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL13A

Gene Name

ribosomal protein L13a

Synonyms

L13A; TSTA1

Species

Homo sapiens

Ensembl Gene

ENSG00000142541

Encoded Proteins

IDBP-246845

ribosomal protein L13a

IDBP-763779

IDBP-762126

IDBP-806884

ribosomal protein L13a

IDBP-806894

ribosomal protein L13a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L13P family of ribosomal proteins that is a component of the 60S subunit. The encoded protein also plays a role in the repression of inflammatory genes as a component of the IFN-gamma-activated inhibitor of translation (GAIT) complex. This gene is co-transcribed with the small nucleolar RNA genes U32, U33, U34, and U35, which are located in the second, fourth, fifth, and sixth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:49487554-49492308

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000391857	ENSP00000375730
ENST00000488946
ENST00000484279	ENSP00000470768
ENST00000472481
ENST00000479992
ENST00000486930
ENST00000476268
ENST00000477613
ENST00000467825	ENSP00000470037
ENST00000474171
ENST00000468655
ENST00000476300
ENST00000624069	ENSP00000485546
ENST00000621674	ENSP00000477755

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0017148	negative regulation of translation
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process
GO:0071346	cellular response to interferon-gamma
GO:1901194	negative regulation of formation of translation preinitiation complex

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0030529	ribonucleoprotein complex
GO:0097452	GAIT complex