InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPL13A

Summary

InnateDB Protein

IDBP-246845.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL13A

Protein Name

ribosomal protein L13a

Synonyms

L13A; TSTA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000375730

InnateDB Gene

IDBG-62892 (RPL13A)

Protein Structure

UniProt Annotation

Function

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA. {ECO:0000269PubMed:14567916, ECO:0000269PubMed:17218275, ECO:0000269PubMed:17921318, ECO:0000269PubMed:23071094}.

Subcellular Localization

Cytoplasm {ECO:0000305PubMed:14567916}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0017148	negative regulation of translation
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process
GO:0071346	cellular response to interferon-gamma
GO:1901194	negative regulation of formation of translation preinitiation complex

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0030529	ribonucleoprotein complex
GO:0097452	GAIT complex