Version 5.4
| Bos taurus Gene: LRAT | |||||
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| Summary | |||||
| InnateDB Gene | IDBG-628938.3 | ||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
| Gene Symbol | LRAT | ||||
| Gene Name | lecithin retinol acyltransferase | ||||
| Synonyms | |||||
| Species | Bos taurus | ||||
| Ensembl Gene | ENSBTAG00000017167 | ||||
| Encoded Proteins |
lecithin retinol acyltransferase
lecithin retinol acyltransferase
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| Protein Structure | |||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||
| Entrez Gene | |||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121207:
The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy. [provided by RefSeq, Jul 2008] The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] |
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| Gene Information | |||||
| Type | Protein coding | ||||
| Genomic Location | Chromosome 17:2652180-2657479 | ||||
| Strand | Reverse strand | ||||
| Band | |||||
| Transcripts |
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| Interactions | |||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||
| NETPATH | |||||
| REACTOME |
The canonical retinoid cycle in rods (twilight vision) pathway
Retinoid metabolism and transport pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Visual phototransduction pathway
Disease pathway
Disease pathway
Retinoid metabolism and transport pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Visual phototransduction pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
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| KEGG |
Retinol metabolism pathway
Retinol metabolism pathway
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| INOH | |||||
| PID NCI |
Visual signal transduction: Cones
Visual signal transduction: Rods
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| Cross-References | |||||
| SwissProt | |||||
| TrEMBL | F1MMN7 Q32LM9 | ||||
| UniProt Splice Variant | |||||
| Entrez Gene | 281285 | ||||
| UniGene | Bt.8135 | ||||
| RefSeq | NM_177503 XM_005217434 | ||||
| HUGO | |||||
| OMIM | |||||
| CCDS | |||||
| HPRD | |||||
| IMGT | |||||
| EMBL | BC109504 DAAA02044107 | ||||
| GenPept | AAI09505 | ||||
| RNA Seq Atlas | 281285 | ||||