InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lrat

Summary

InnateDB Gene

IDBG-154487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrat

Gene Name

lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)

Synonyms

1300010A18Rik; AI449251

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028003

Encoded Proteins

IDBP-154489

lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121207:
The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy. [provided by RefSeq, Jul 2008]
The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:82892579-82903973

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029632

ENSMUSP00000029632

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0008374	O-acyltransferase activity
GO:0019841	retinol binding
GO:0047173	phosphatidylcholine-retinol O-acyltransferase activity

Biological Process

GO:0006653	1,2-diacyl-sn-glycero-3-phosphocholine metabolic process
GO:0006776	vitamin A metabolic process
GO:0007601	visual perception
GO:0042572	retinol metabolic process
GO:0042573	retinoic acid metabolic process
GO:0050896	response to stimulus

Cellular Component

GO:0005771	multivesicular body
GO:0005789	endoplasmic reticulum membrane
GO:0005791	rough endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm