InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ITGA2

Summary

InnateDB Gene

IDBG-629414.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA2

Gene Name

integrin alpha-2 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019289

Encoded Proteins

IDBP-680813

integrin alpha-2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164171:
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:25984555-26089593

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025685

ENSBTAP00000025685

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0038064	collagen receptor activity

Biological Process

GO:0006929	substrate-dependent cell migration
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0031589	cell-substrate adhesion
GO:0033627	cell adhesion mediated by integrin
GO:0038065	collagen-activated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045178	basal part of cell