|Homo sapiens Gene: PTX3|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||pentraxin 3, long|
pentraxin 3, long
|Useful resources||Stemformatics EHFPI ImmGen|
PTX3 is a multifunctional soluble molecule involved in inflammation and innate immunity. It is a unique factor H (FH) ligand in that it can bind both of the two hot-spots of FH and can participate in the localization of functionally active FH.
PTX3, an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and glycosylation-dependent regulation of inflammation.
PTX3, an inflammation-associated long pentraxin, plays key roles in innate immunity, female fertility and vascular biology. PTX3 octamer contains two fibroblast growth factor 2 (FGF2) binding sites and this quaternary organization is required for the anti-angiogenic function of PTX3.
PTX3 is produced by innate immunity cells (e.g. PMN, macrophages, dendritic cells) and it interacts with several ligands to play an essential role in innate immunity, tuning inflammation and matrix deposition. PTX3 provides a paradigm for the mode of action of humoral innate immunity.
PTX3, serum amyloid P component (SAP) and C-reactive protein (CRP) belong to the pentraxin family of pattern recognition molecules involved in tissue homeostasis and innate immunity. PTX3 heterocomplexes with mannose-binding lectin (MBL) to trigger cross-activation of the complement system.
PTX3 production is up-regulated in response to serum amyloid A, and contributes to the inflammatory pathogenesis of atherosclerosis.
FCN3 and PTX3 are soluble oligomeric pattern-recognition molecules that interact with each other and act synergistically to activate the lectin complement pathway.
PTX3 forms a complex with components of neutrophil extracellular traps in septic patients.
Sputum PTX3 level are lower in cystic fibrosis patients due to proteolytic cleavage by Aspergillus fumigatus.
PTX3 acts as an extrinsic oncosuppressor gene by regulating Complement-dependent, macrophage-sustained, tumor-promoting inflammation.
PTX3 plays a non-redundant protective role in orchestrating tissue repair and remodeling by interacting with fibrin and plasminogen.
|InnateDB Annotation from Orthologs|
[Mus musculus] Ptx3 production is up-regulated in response to serum amyloid A, and contributes to the inflammatory pathogenesis of atherosclerosis. (Demonstrated in human)
[Mus musculus] Ptx3 forms a complex with components of neutrophil extracellular traps in septic patients. (Demonstrated in human)
[Mus musculus] Ptx3 acts as an extrinsic oncosuppressor gene by regulating Complement-dependent, macrophage-sustained, tumor-promoting inflammation.
|Summary||Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.|
|Genomic Location||Chromosome 3:157436789-157443628|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|UniProt Splice Variant|
|RNA Seq Atlas|