InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTX3

Summary

InnateDB Protein

IDBP-62947.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTX3

Protein Name

pentraxin 3, long

Synonyms

TNFAIP5; TSG-14;

Species

Homo sapiens

Ensembl Protein

ENSP00000295927

InnateDB Gene

IDBG-62945 (PTX3)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001849	complement component C1q binding
GO:0001872	(1->3)-beta-D-glucan binding
GO:0046790	virion binding

Biological Process

GO:0001878	response to yeast
GO:0006954	inflammatory response
GO:0008228	opsonization
GO:0045087	innate immune response (InnateDB)
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0046597	negative regulation of viral entry into host cell
GO:0050766	positive regulation of phagocytosis
GO:1903016	negative regulation of exo-alpha-sialidase activity
GO:1903019	negative regulation of glycoprotein metabolic process