Version 5.4
| Bos taurus Gene: BT.44506 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-629714.3 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | BT.44506 | ||||||||||||||||||||||
| Gene Name | clathrin heavy chain 1 | ||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000016708 | ||||||||||||||||||||||
| Encoded Proteins |
clathrin heavy chain 1
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] CLTC functions as a built-in molecular brake that ensures a tight control of basal NFKB activation and gene expression in un-stimulated cells. Defects in CLTC expression could potentially lead to chronic inflammation disorder.
[Mus musculus] Cltc functions as a built-in molecular brake that ensures a tight control of basal NFKB activation and gene expression in un-stimulated cells. Defects in Cltc expression could potentially lead to chronic inflammation disorder.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141367:
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008] Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 19:10848574-10889456 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | |||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 137 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
KitReceptor pathway
TCR pathway
IL-7 pathway
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| REACTOME |
Formation of annular gap junctions pathway
Gap junction degradation pathway
PCP/CE pathway pathway
Developmental Biology pathway
WNT5A-dependent internalization of FZD4 pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Axon guidance pathway
Signal Transduction pathway
Gap junction trafficking pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
Gap junction trafficking and regulation pathway
Membrane Trafficking pathway
WNT5A-dependent internalization of FZD4 pathway
Signaling by Wnt pathway
Membrane Trafficking pathway
beta-catenin independent WNT signaling pathway
Lysosome Vesicle Biogenesis pathway
Immune System pathway
Golgi Associated Vesicle Biogenesis pathway
PCP/CE pathway pathway
MHC class II antigen presentation pathway
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Adaptive Immune System pathway
Signal Transduction pathway
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| KEGG |
Lysosome pathway
Endocytosis pathway
Huntington's disease pathway
Bacterial invasion of epithelial cells pathway
Lysosome pathway
Huntington's disease pathway
Endocytosis pathway
Bacterial invasion of epithelial cells pathway
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| INOH | |||||||||||||||||||||||
| PID NCI |
Arf6 trafficking events
FAS (CD95) signaling pathway
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | F1MPU0 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 281080 | ||||||||||||||||||||||
| UniGene | |||||||||||||||||||||||
| RefSeq | |||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | DAAA02048338 DAAA02048339 | ||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | 281080 | ||||||||||||||||||||||