Homo sapiens Gene: CLTC
Summary
InnateDB Gene IDBG-61767.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLTC
Gene Name clathrin, heavy chain (Hc)
Synonyms CHC; CHC17; CLH-17; CLTCL2; Hc;
Species Homo sapiens
Ensembl Gene ENSG00000141367
Encoded Proteins
clathrin, heavy chain (Hc)
clathrin, heavy chain (Hc)
clathrin, heavy chain (Hc)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CLTC functions as a built-in molecular brake that ensures a tight control of basal NFKB activation and gene expression in un-stimulated cells. Defects in CLTC expression could potentially lead to chronic inflammation disorder.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cltc functions as a built-in molecular brake that ensures a tight control of basal NFKB activation and gene expression in un-stimulated cells. Defects in Cltc expression could potentially lead to chronic inflammation disorder.
Entrez Gene
Summary Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:59619689-59696956
Strand Forward strand
Band q23.1
Transcripts
ENST00000269122 ENSP00000269122
ENST00000393043 ENSP00000376763
ENST00000472129
ENST00000483176 ENSP00000463068
ENST00000466513
ENST00000496076
ENST00000472651 ENSP00000465200
ENST00000475458 ENSP00000461977
ENST00000498711
ENST00000585198
ENST00000579456 ENSP00000462252
ENST00000580081 ENSP00000462592
ENST00000579815
ENST00000584313 ENSP00000463336
ENST00000621829 ENSP00000479606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 167 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 167 [view]
Protein-Protein 167 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0005198 structural molecule activity
GO:0005488 binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0032051 clathrin light chain binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006898 receptor-mediated endocytosis
GO:0007067 mitotic nuclear division
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031623 receptor internalization
GO:0033572 transferrin transport
GO:0045087 innate immune response (InnateDB)
GO:0061024 membrane organization
GO:1900126 negative regulation of hyaluronan biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030118 clathrin coat
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit
GO:0030136 clathrin-coated vesicle
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032588 trans-Golgi network membrane
GO:0042470 melanosome
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0071439 clathrin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
KitReceptor pathway
TCR pathway
IL-7 pathway
REACTOME
PCP/CE pathway pathway
Developmental Biology pathway
Gap junction degradation pathway
WNT5A-dependent internalization of FZD4 pathway
beta-catenin independent WNT signaling pathway
Formation of annular gap junctions pathway
Signaling by Wnt pathway
Axon guidance pathway
Signal Transduction pathway
Gap junction trafficking pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
Gap junction trafficking and regulation pathway
Membrane Trafficking pathway
KEGG
Lysosome pathway
Endocytosis pathway
Huntington's disease pathway
Bacterial invasion of epithelial cells pathway
INOH
PID BIOCARTA
PID NCI
Arf6 trafficking events
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.491351
RefSeq NM_001288653 NM_004859 XM_005257012
HUGO
OMIM
CCDS CCDS32696 CCDS74115
HPRD 00350
IMGT
EMBL
GenPept
RNA Seq Atlas