Version 5.4
Bos taurus Gene: ATM
Summary
InnateDB Gene IDBG-629882.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATM
Gene Name serine-protein kinase ATM
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003111
Encoded Proteins
IDBP-681447
ataxia telangiectasia mutated
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25692705
[Mus musculus] Unrepaired DNA lesions induce type I interferons via the Tmem173 pathway, resulting in enhanced anti-viral and anti-bacterial responses in Atm (-/-) mice.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149311:
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:18119201-18265060
Strand Forward strand
Band
Transcripts
ENSBTAT00000040104 ENSBTAP00000039884
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 127 interaction(s) predicted by orthology.
Predicted by orthology
Total 127 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004677 DNA-dependent protein kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0032403 protein complex binding
GO:0046983 protein dimerization activity
GO:0047485 protein N-terminus binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000723 telomere maintenance
GO:0001756 somitogenesis
GO:0002331 pre-B cell allelic exclusion
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0007050 cell cycle arrest
GO:0007094 mitotic spindle assembly checkpoint
GO:0007292 female gamete generation
GO:0007420 brain development
GO:0007507 heart development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010212 response to ionizing radiation
GO:0016310 phosphorylation
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0030889 negative regulation of B cell proliferation
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0042159 lipoprotein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525 positive regulation of neuron apoptotic process
GO:0046777 protein autophosphorylation
GO:0048599 oocyte development
GO:0051402 neuron apoptotic process
GO:0071044 histone mRNA catabolic process
GO:0071480 cellular response to gamma radiation
GO:0072434 signal transduction involved in mitotic G2 DNA damage checkpoint
GO:0090399 replicative senescence
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005819 spindle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000149311
View Gene Order
ENSMUSG00000034218
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_897
G2/M DNA damage checkpoint pathway
REACT_20549
Autodegradation of the E3 ubiquitin ligase COP1 pathway
REACT_309
Stabilization of p53 pathway
REACT_1625
p53-Dependent G1 DNA Damage Response pathway
REACT_1614
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
REACT_2160
p53-Independent DNA Damage Response pathway
REACT_18265
Regulation of the Fanconi anemia pathway pathway
REACT_18410
Fanconi Anemia pathway pathway
REACT_97
Recruitment of repair and signaling proteins to double-strand breaks pathway
REACT_1924
ATM mediated phosphorylation of repair proteins pathway
REACT_204
ATM mediated response to DNA double-strand break pathway
REACT_27271
Meiotic recombination pathway
REACT_85
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_120956
Cellular responses to stress pathway
REACT_1208
p53-Independent G1/S DNA damage checkpoint pathway
REACT_200780
Regulation of HSF1-mediated heat shock response pathway
REACT_1874
Homologous Recombination Repair pathway
REACT_828
G2/M Checkpoints pathway
REACT_2054
Double-Strand Break Repair pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
REACT_200819
Cellular response to heat stress pathway
REACT_1587
Homologous recombination repair of replication-independent double-strand breaks pathway
REACT_2254
G1/S DNA Damage Checkpoints pathway
REACT_111183
Meiosis pathway
REACT_216
DNA Repair pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_27235
Meiotic Recombination pathway
REACT_251314
ATM mediated phosphorylation of repair proteins pathway
REACT_233330
p53-Independent G1/S DNA damage checkpoint pathway
REACT_212633
Autodegradation of the E3 ubiquitin ligase COP1 pathway
REACT_200794
Mus musculus biological processes pathway
REACT_230172
Recruitment of repair and signaling proteins to double-strand breaks pathway
REACT_188957
Cellular responses to stress pathway
REACT_237804
p53-Independent DNA Damage Response pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_238355
Double-Strand Break Repair pathway
REACT_257943
p53-Dependent G1 DNA Damage Response pathway
REACT_251223
G2/M DNA damage checkpoint pathway
REACT_254524
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_188804
Cell Cycle pathway
REACT_256790
Stabilization of p53 pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_233397
DNA Repair pathway
REACT_232069
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
REACT_188820
Cellular Senescence pathway
REACT_232842
Fanconi Anemia pathway pathway
REACT_235397
G2/M Checkpoints pathway
REACT_224790
Cellular response to heat stress pathway
REACT_246312
G1/S DNA Damage Checkpoints pathway
REACT_222185
Regulation of HSF1-mediated heat shock response pathway
REACT_198624
Meiosis pathway
REACT_198629
Meiotic recombination pathway
REACT_245922
Homologous Recombination Repair pathway
REACT_237642
ATM mediated response to DNA double-strand break pathway
REACT_260435
Regulation of the Fanconi anemia pathway pathway
REACT_251264
Homologous recombination repair of replication-independent double-strand breaks pathway
KEGG
hsa04110
Cell cycle pathway
hsa04210
Apoptosis pathway
hsa04115
p53 signaling pathway pathway
mmu04115
p53 signaling pathway pathway
mmu04110
Cell cycle pathway
mmu04210
Apoptosis pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
p53regulationpathway
p53 pathway
e2f_pathway
E2F transcription factor network
nfkappabcanonicalpathway
Canonical NF-kappaB pathway
bard1pathway
BARD1 signaling events
atm_pathway
ATM pathway
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
telomerasepathway
Regulation of Telomerase
p38_mkk3_6pathway
p38 MAPK signaling pathway
Cross-References
SwissProt
TrEMBL E1BEI6
UniProt Splice Variant
Entrez Gene 526824
UniGene Bt.62037
RefSeq NM_001205935 XM_005215785
HUGO HGNC:795
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02040194 DAAA02040195
GenPept
RNA Seq Atlas 526824

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca