Bos taurus Gene: FKBP5
Summary
InnateDB Gene IDBG-629966.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FKBP5
Gene Name peptidyl-prolyl cis-trans isomerase FKBP5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000047502
Encoded Proteins
FK506 binding protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000096060:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:9521254-9637802
Strand Reverse strand
Band
Transcripts
ENSBTAT00000064387 ENSBTAP00000054371
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0031072 heat shock protein binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL G3MXV0
UniProt Splice Variant
Entrez Gene 535704
UniGene Bt.53635
RefSeq NM_001192862 XM_005223348 XM_005223349 XM_005223350
HUGO HGNC:3721
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02054955 DAAA02054956 DAAA02054957
GenPept
RNA Seq Atlas 535704
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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