InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fkbp5

Summary

InnateDB Gene

IDBG-158514.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fkbp5

Gene Name

FK506 binding protein 5

Synonyms

D17Ertd592e; Dit1; FKBP-5; FKBP51

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024222

Encoded Proteins

IDBP-158518

FK506 binding protein 5

IDBP-251045

FK506 binding protein 5

IDBP-537167

FK506 binding protein 5

IDBP-714125

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000096060:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:28399095-28517524

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000079413	ENSMUSP00000078382
ENSMUST00000114792	ENSMUSP00000110440
ENSMUST00000143685
ENSMUST00000153744	ENSMUSP00000116466
ENSMUST00000147716
ENSMUST00000177939	ENSMUSP00000136245

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005528	FK506 binding
GO:0031072	heat shock protein binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0018208	peptidyl-proline modification
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000096060

View Gene Order

ENSBTAG00000047502

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

reg_gr_pathway

Glucocorticoid receptor regulatory network

Cross-References

SwissProt

Q64378

TrEMBL

B8JJC2 Q4FJN2

UniProt Splice Variant

Entrez Gene

14229

UniGene

Mm.276405 Mm.488793

RefSeq

NM_010220

OMIM

CCDS

CCDS37528

HPRD

IMGT

MGI ID

MGI:104670

MGI Symbol

Fkbp5

EMBL

AC154912 AK169795 BC015260 CH466606 CT010372 U16959 U36220

GenPept

AAA86983 AAA89162 AAH15260 BAE41371 CAJ18579 EDL22576

RNA Seq Atlas

14229