Mus musculus Gene: Fkbp5
Summary
InnateDB Gene IDBG-158514.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fkbp5
Gene Name FK506 binding protein 5
Synonyms D17Ertd592e; Dit1; FKBP-5; FKBP51;
Species Mus musculus
Ensembl Gene ENSMUSG00000024222
Encoded Proteins
FK506 binding protein 5
FK506 binding protein 5
FK506 binding protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000096060:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:28399095-28517524
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000079413 ENSMUSP00000078382
ENSMUST00000114792 ENSMUSP00000110440
ENSMUST00000143685
ENSMUST00000153744 ENSMUSP00000116466
ENSMUST00000147716
ENSMUST00000177939 ENSMUSP00000136245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0031072 heat shock protein binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0018208 peptidyl-proline modification
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Glucocorticoid receptor regulatory network
Cross-References
SwissProt Q64378
TrEMBL B8JJC2 Q4FJN2
UniProt Splice Variant
Entrez Gene 14229
UniGene Mm.276405 Mm.488793
RefSeq NM_010220
OMIM
CCDS CCDS37528
HPRD
IMGT
MGI ID MGI:104670
MGI Symbol Fkbp5
EMBL AC154912 AK169795 BC015260 CH466606 CT010372 U16959 U36220
GenPept AAA86983 AAA89162 AAH15260 BAE41371 CAJ18579 EDL22576
RNA Seq Atlas 14229