Version 5.4
Homo sapiens Gene: FCGRT
Summary
InnateDB Gene IDBG-63001.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCGRT
Gene Name Fc fragment of IgG, receptor, transporter, alpha
Synonyms alpha-chain; FCRN
Species Homo sapiens
Ensembl Gene ENSG00000104870
Encoded Proteins
IDBP-63003
Fc fragment of IgG, receptor, transporter, alpha
IDBP-383290
Fc fragment of IgG, receptor, transporter, alpha
IDBP-760238
IDBP-764990
IDBP-760993
IDBP-763263
IDBP-765731
IDBP-763192
IDBP-759726
IDBP-764859
IDBP-765072
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49506816-49526333
Strand Forward strand
Band q13.33
Transcripts
ENST00000221466 ENSP00000221466
ENST00000426395 ENSP00000410798
ENST00000452439
ENST00000593381 ENSP00000472256
ENST00000598319 ENSP00000472604
ENST00000596975 ENSP00000471118
ENST00000594823
ENST00000596147
ENST00000598936
ENST00000598491 ENSP00000472350
ENST00000599701 ENSP00000472794
ENST00000595677
ENST00000598927 ENSP00000469968
ENST00000595881
ENST00000599988 ENSP00000471300
ENST00000600273 ENSP00000469933
ENST00000598076 ENSP00000471232
ENST00000593431
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019864 IgG binding
GO:0030881 beta-2-microglobulin binding
Biological Process
GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0038094 Fc-gamma receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003420
View Gene Order
ENSBTAG00000013926
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.111903
RefSeq NM_001136019 NM_004107 XM_005258657
HUGO
OMIM
CCDS CCDS12770
HPRD 03257
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca