InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FCGRT

Summary

InnateDB Protein

IDBP-383290.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCGRT

Protein Name

Fc fragment of IgG, receptor, transporter, alpha

Synonyms

alpha-chain; FCRN;

Species

Homo sapiens

Ensembl Protein

ENSP00000410798

InnateDB Gene

IDBG-63001 (FCGRT)

Protein Structure

UniProt Annotation

Function

Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019864	IgG binding

Biological Process

GO:0002416	IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0038094	Fc-gamma receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein

PFAM

PF00129
PF07654

PRINTS

PIRSF

SMART

SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P55899